Cytotec misoprostol kegunaannya

Cytotec misoprostol kegunaannya. Several reports in the literature associate the use of this drug during the first trimester with skull defects, cranial nerve palsies, facial malformations, and limb defects. Misoprostol should be promptly discontinued if pregnancy occurs during treatment with this agent for the approved indication. Misoprostol should not be used for reducing the risk of NSAID-induced ulcers in females of childbearing potential unless the patient is at high risk of complications from gastric ulcers associated with use of the NSAID, or is at high risk of developing gastric ulceration.

In such patients, misoprostol may be prescribed if the patient 1 exhibits a negative serum pregnancy testing within 2 weeks of initiating therapy, 2 follows contraception requirements, using effective and reliable birth control during misoprostol use, 3 receives both oral and written warnings on the potential hazards, and 4 initiates therapy only on the second or third day of the next normal menstrual period. The manufacturer does not contraindicate the use of misoprostol during or following labor and obstetric delivery for off-label uses and recognizes these off-label uses within the special populations information of the label. Misoprostol is widely used off-label in obstetric practice as a cervical ripening agent to induce labor, for term obstetric delivery, for treatment of serious postpartum hemorrhage in the presence of uterine atony, and as part of the FDA-approved regimen for use with mifepristone RU-486 for termination of pregnancy of 49 days or less.